February 2012
| Date | Time | Home Team | Away Team | Venue |
| 04 SAT | 4:30 PM | Real Espana | Washington, DC | Tad Gormley Stadium |
| 25 SAT | 1:00 PM | Rapids | Seattle, WA | Blackbaud Stadium |
| 29 WED | 5:30 PM | Fire | Bridgeview, IL | Blackbaud Stadium |
March 2012
| Date | Time | Home Team | Away Team | Venue |
| 03 SAT | 6:15PM CST | Charleston | Chicago | Blackbaud Stadium |
| 17 SAT | 1:00PM CDT | Monteal | Chicago | Olympic Stadium |
| 24 SAT | 7:30PM CDT | Chicago | Philadelphia | Toyota Park |
April 2012
| Date | Time | Home Team | Away Team | Venue |
| 01 SUN | 6:00PM CDT | Colorado | Chicago | Dick’s Sporting Goods Park |
| 15 SUN | 6:00PM CDT | Chicago | Houston | Toyota Park |
| 21 SAT | 2:30PM CDT | Toronto FC | Chicago | BMO Field |
| 28 SAT | 7:30PM CDT | Chicago | Seattle | Toyota Park |
May 2012
| Date | Time | Home Team | Away Team | Venue |
| 04 FRI | 10:00PM CDT | Chivas USA | Chicago | Home Depot Center |
| 09 WED | 7:30PM CDT | Chicago | Real Salt Lake | Toyota Park |
| 12 SAT | 7:30PM CDT | Chicago | Sporting KC | Toyota Park |
| 20 SUN | 6:00PM CDT | Portland | Chicago | Jeld-Wen Field |
| 23 WED | 7:30PM CDT | Chicago | FC Dallas | Toyota Park |
| 26 SAT | 6:00PM CDT | Columbus | Chicago | Columbus Crew Stadium |
June 2012
| Date | Time | Home Team | Away Team | Venue |
| 02 SAT | 6:30PM CDT | New England | Chicago | Gillette Stadium |
| 17 Sun | 4:00PM CDT | Chicago | New York | Toyota Park |
| 23 SAT | 7:30PM CDT | Chicago | Columbus | Toyota Park |
| 29 FRI | 7:00PM CDT | Sporting KC | Chicago | Livestrong Sporting Park |
July 2012
| Date | Time | Home Team | Away Team | Venue |
| 03 Tues | 7:30PM CDT | Houston | Chicago | BBVA Compass Stadium |
| 08 Sun | 2:00PM CDT | Chicago | Los Angeles | Toyota Park |
| 14 SAT | 7:30PM CDT | Chicago | Vancouver | Toyota Park |
| 18 WED | 12:00PM CDT | New York | Chicago | Red Bull Arena |
| 21 SAT | 3:00PM CDT | Toronto FC | Chicago | BMO Field |
| 28 SAT | 9:30PM CDT | San Jose | Chicago | Buck Shaw Stadium |
August 2012
| Date | Time | Home Team | Away Team | Venue |
| 04 SAT | 7:30PM CDT | Chicago | Toronto FC | Toyota Park |
| 12 Sun | 6:00PM CDT | Philadelphia | Chicago | PPL Park |
| 18 SAT | 7:30PM CDT | Chicago | New England | Toyota Park |
| 22 WED | 6:30PM CDT | D.C. United | Chicago | RFK Stadium |
September 2012
| Date | Time | Home Team | Away Team | Venue |
| 02 SAT | 6:00PM CDT | Chicago | Houston | Toyota Park |
| 15 Sun | 7:30PM CDT | Chicago | Montreal | Toyota Park |
| 22 SAT | 7:30PM CDT | Chicago | Columbus | Toyota Park |
| 28 WED | 7:30PM CDT | Sporting KC | Chicago | Livestrong Sporting Park |
October 2012
| Date | Time | Home Team | Away Team | Venue |
| 03 WED | 7:30PM CDT | Chicago | Philadelphia | Toyota Park |
| 06 SAT | 2:30PM CDT | New York | Chicago | Red Bull Arena |
| 20 SAT | 6:30PM CDT | New England | Chicago | Gillette Stadium |
| 27 SAT | 3:00PM CDT | Chicago | D.C. United | Toyota Park |