February 2012
| Date | Time | Home Team | Away Team | Venue |
| 24 FRI | 5:00PM CST | Sporting KC | Houston Dynamo | Walt Disney World Pro Soccer |
| 26 SUN | 12:00PM CST | Vancouver Whitecaps | Houston Dynamo | Walt Disney World Pro Soccer |
| 29 WED | 6:00PM CDT | Houston Dynamo | Montreal Impact | Walt Disney World Pro Soccer |
March 2012
| Date | Time | Home Team | Away Team | Venue |
| 11 SUN | 6:00PM CDT | Chivas USA | Houston Dynamo | The Home Depot Center |
| 18 SUN | TBD | San Jose Earthquakes | Houston Dynamo | Buck Shaw Stadium |
| 23 FRI | 9:00PM CDT | Seattle Sounders | Houston Dynamo | CenturyLink Field |
April 2012
| Date | Time | Home Team | Away Team | Venue |
| 15 SUN | 6:00PM CDT | Chicago Fire | Houston Dynamo | Toyota Park |
| 21 SAT | 6:30PM CDT | Columbus Crew | Houston Dynamo | Crew Stadium |
| 28 SAT | 6:30PM CDT | D.C. United | Houston Dynamo | RFK Stadium |
May 2012
| Date | Time | Home Team | Away Team | Venue |
| 09 WED | 6:00PM CDT | New York Red Bulls | Houston Dynamo | Red Bull Arena |
| 12 SAT | 3:30PM CDT | Houston Dynamo | D.C. United | BBVA Compass Stadium |
| 15 TUE | 7:30PM CDT | Houston Dynamo | Portland Timbers | BBVA Compass Stadium |
| 19 SAT | 6:30PM CDT | New England Revolution | Houston Dynamo | Gillette Stadium |
| 26 SAT | 1:30PM CDT | Houston Dynamo | LA Galaxy | BBVA Compass Stadium |
June 2012
| Date | Time | Home Team | Away Team | Venue |
| 10 SUN | TBD | Vancouver Whitecaps | Houston Dynamo | BC Place |
| 16 SAT | 4:00PM CDT | Houston Dynamo | FC Dallas | BBVA Compass Stadium |
| 20 WED | 8:00PM CDT | Houston Dynamo | Toronto FC | BBVA Compass Bank Stadium |
| 23 SAT | 6:30PM CDT | Montreal Impact | Houston Dynamo | Saputo Stadium |
| 30 SAT | 7:30PM CDT | Houston Dynamo | Philadelphia Union | BBVA Compass Bank Stadium |
July 2012
| Date | Time | Home Team | Away Team | Venue |
| 03 TUE | 7:30PM CDT | Houston Dynamo | Chicago Fire | BBVA Compass Stadium |
| 07 SAT | 7:30PM CDT | Sporting KC | Houston Dynamo | LIVESTRONG Sporting Park |
| 15 SUN | 8:00PM CDT | Houston Dynamo | D.C. United | BBVA Compass Stadium |
| 18 WED | 7:30PM CDT | Houston Dynamo | Sporting KC | BBVA Compass Stadium |
| 21 SAT | 7:30PM CDT | Houston Dynamo | Montreal Impact | BBVA Compass Stadium |
| 28 SAT | 3:30PM CDT | Toronto FC | Houston Dynamo | BMO Field |
August 2012
| Date | Time | Home Team | Away Team | Venue |
| 03 FRI | 7:00PM CDT | Houston Dynamo | New York Red Bulls | BBVA Compass Stadium |
| 10 FRI | 7:00PM CDT | New York Red Bulls | Houston Dynamo | Red Bull Arena |
| 19 SUN | 8:00PM CDT | Houston Dynamo | Columbus Crew | BBVA Compass Stadium |
| 25 SAT | 7:30PM CDT | Houston Dynamo | Toronto FC | BBVA Compass Stadium |
September 2012
| Date | Time | Home Team | Away Team | Venue |
| 02 SUN | 6:00PM CDT | Chicago Fire | Houson Dynamo | Toyota Park |
| 06 THU | 7:30PM CDT | Houston Dynamo | Real Salt Lake | BBVA Compass Stadium |
| 14 FRI | 7:30PM CDT | Sporting KC | Houston Dynamo | LIVESTRONG Sporting Park |
| 23 SUN | 4:00PM CDT | Philadelphia Union | Houston Dynamo | PPL Park |
| 29 SAT | 7:30PM CDT | Houston Dynamo | New England Revolution | BBVA Compass Stadium |
October 2012
| Date | Time | Home Team | Away Team | Venue |
| 06 SUN | 7:30PM CDT | Houston Dynamo | Montreal Impact | BBVA Compass Stadium |
| 20 SUN | 6:30PM CDT | Houston Dynamo | Philadelphia Union | BBVA Compass Stadium |
| 27 SUN | 8:00PM CDT | Colorado Rapids | Houston Dynamo | Dick’s Sporting Goods Park |